Potsdam Minisymposium, October 1998

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Dear colleagues,


overleaf please find the final program of our minisymposium "Vibrational Spectroscopy: New Tool in Medicine"

The main goal of the minisymposium is to stimulate an open discussion between medical doctors and spectroscopists about the need for and potentials of vibrational spectroscopic tools that provide:

  • more adequate diagnosis and prognosis than presently possible
  • in situ and in vivo (non or minimally invasive) diagnosis
  • guidance and monitoring during clinical interventions
  • monitoring e.g. of blood analytes or drugs
  • rapid detection and identification of life-threatening microbial pathogens

We have chosen to set up this meeting in a way that will stimulate discussions and a free flow of ideas in an atmosphere as open as possible. For this reason the meeting will be loosely structured in sessions around the themes listed above. For each session we have asked 4 to 6 speakers to briefly introduce (10 to maximum 15 minutes) the problems from a MDís perspective and from a spectroscopistís perspective. These introductions will ideally give a good overview over clinical problems and questions and the clinical routines currently in use, as well as of the potentials and limitations of spectroscopy in tackling these. This means that about 30-50% of the time will be available for discussion. Participants are free to take the opportunity to briefly present relevant data or techniques or additional clinical needs (bring overhead transparencies with results relevant to any of the themes).

In order to make this work successful a good deal of preparation is required of all participants!

Of MDís we ask to try and formulate their problems/questions as much as possible in terms that are of help to spectroscopists (for example: define the areas where the need of new diagnostic tools is evident, try to give relevant (patho-)physiologic concentration ranges of analytes of interest, try to give time-frames available for a spectroscopic assessment during surgery). Of spectroscopists we ask to keep technical details to a minimum.


Looking forward to meeting you in October


H. Fabian, J. Lichey, D. Naumann, G.J. Puppels

Friday, October 16th
14:00 - 15:00
Robert Koch-Institute, Nordufer 20, D-13353 Berlin
  15:00 - 18:00 Bus Tour through Berlin

18:00 - 19:00 Bus Transfer to the Inselhotel, Potsdam-Hermannswerder

19:30 Welcome Reception, Dinner (Schlosshotel Cecilienhof)

Saturday, October 17th
9:00 - 9:30
Opening Remarks (J. Lichey, Berlin)

Vibrational Spectroscopy (the technique, advantages and problems): An Introduction
(H.H. Mantsch, Winnipeg & G.J. Puppels, Rotterdam)

9:30 - 11:30
Improving the Quality of Diagnosis and Prognosis (I)
Moderation: H.H. Mantsch (Winnipeg) & J. Lichey (Berlin)


      M. Diem (City University of New York, USA)

      H. Fabian (Max-Delbrück-Center for Molecular Medicine, Berlin, Germany)

      A.A. Ismail (McGill University, Ste. Anne de Bellevue, Canada)

      J. Lichey (Medical Center for Lung Diseases and Thoracic Surgery, Berlin)

      D. McNaughton (Monash University Clayton, Australia)

      C.P. Schultz (Institute for Biodiagnostics, NRC Canada, Winnipeg, Canada)

      Clinical Views and Problems
      Sensitivity of Infrared Spectral Features Toward Differentiation, Maturation

      Cell Cycle Dependence and State of Health of Human Cells
      Infrared Analysis of Tumor Cell Lines and Breast Tissues Sections
      Diagnosis and Prognosis of Leukemia by Infrared Spectroscopy

      Examination of Cervical Smears by FTIR Spectroscopy

      Characterization of Activated Lymphocytes by FT-IR

Coffee Break

12:00 - 13:45
Improving the Quality of Diagnosis and Prognosis (II)
Moderation: H. Fabian (Berlin) & H. Barr (Gloucester)


      H. Barr (Gloucestershire Royal Hospital, Gloucester, England)

      D.L. Farkas (Carnegie Mellon University, Pittsburgh, USA)

      P. Lasch (Robert Koch-Institute, Berlin, Germany)

      E.N. Lewis (National Institute of Health, Bethesda, USA)

      D.L. B.Wetzel (Kansas University, Kansas City, USA)

      Barrett's Oesophagus, Prospects for Endoscopic Diagnosis

      Multiwavelength and Spectral Optical Bioimaging

      Spectroscopic Bioimaging Utilizing Infrared Focal-Plane Arrays

      Histopathological Tissue Characterization by FT-IR Microspectroscopy

      Challenges and Recent Achievements in FT-IR Microspectroscopy



15:00 - 17:15
Improving the Quality of Diagnosis and Prognosis (III)
Moderation: D. Naumann (Berlin) & K.T. Moesta (Berlin)
  U. Bindig (Laser-und Medizin-Technologie GmbH, Berlin, Germany)

R.F. Bruch (University of Nevada, Reno, USA)

L. Chiriboga (City University of New York, USA)

H.H. Mantsch (Institute for Biodiagnostics, NRC Canada, Winnipeg, Canada)

M. Sowa (Institute for Biodiagnostics, NRC Canada, Winnipeg, Canada)

      State-of-the-Art of Biophysical Techniques for in vivo Diagnosis, Problems and Limitations, Fiber Optic Probes

      IR-Fiber Optics for Remote Spectroscopy in vivo of Tissues and Body Fluids

      IR-Spectrometry as an Analytical Tool for Tissue Diagnostics

      Infrared Spectroscopic Studies with Hearts and Lungs
      Near Infrared Spectroscopic Imaging and Reconstructive Surgery


Coffee Break

17:45 - 19:15
Improving the Quality of Diagnosis and Prognosis (IV)
Moderation: D. Wetzel (Kansas) & K.J.G. Schmailzl (Neuruppin)
      H.P.J. Buschman (Leiden University Medical Center, The Netherlands)

      A. Mahadevan-Jansen (Vanderbilt University, Nashville, USA)

      G.J. Puppels (Erasmus University Rotterdam, The Netherlands)

      J. S. Robinson Jr. (Neurological Institute at The Medical Center of Central Georgia)

      M.G. Shim (Ontario Cancer Institute, Toronto, Canada)



      Medical Applications of Raman Spectroscopy

      In vivo Tissue Characterization by Raman Spectroscopy

      Histochemistry of Atherosclerosis by Raman Spectroscopy

      Neurosurgical Analysis and Raman Spectroscopy

      NIR Raman Spectroscopy for Cancer and Precancer Detection in vivo


20:00 Dinner

Sunday, October 18th
9:00 - 10:30
Spectroscopy as an Aid in Clinical Procedures: Clinical Chemistry
Moderation: A.A. Ismail (Ste. Anne de Bellevue) &
H.A. Bruining (Rotterdam)


      H.A. Bruining (Erasmus University Rotterdam, The Netherlands)

      H.M. Heise (Inst. f. Spektrochemie u. Angewandte Spektroskopie, Dortmund)

      Y. Ozaki (Kwansei-Gakuin University, Nishinomiya, Japan)

      W. Petrich (Roche Diagnostics Boehringer Mannheim GmbH, Germany)

      What Is Needed in the IC-Unit and in Blood Chemistry?

      Blood Volume Measurements, Determination of Hydroxyethylstarch in Whole Blood

      Enzyme-Immunoassay Utilizing Surface-Enhanced Raman Scattering

      Disease Pattern Recognition from Human Blood by FT-IR

Coffee Break


10:45 - 12:30
Spectroscopy as an Aid in Clinical Procedures: Clinical Microbiology
Moderation: G.J. Puppels (Rotterdam) & H. Labischinski (Wuppertal)

      R. Goodacre (University of Wales, Aberystwyth, Wales)

      L.-P. Choo-Smith (Erasmus University Rotterdam, The Netherlands)

      M. Manfait (UFR de Pharmacie, Reims, France)

      D. Naumann (Robert Koch-Institute, Berlin, Germany)

      J. Schmitt (Dept. of Aquatic Microbiology, University of Duisburg)


      Requirements for Modern Techniques in Clinical Microbiology, Problematic Pathogens

      Rapid Characterization of Microbial Pathogens by FT-IR

      Raman Spectroscopy of Pathogens

      Cell-Drug Interactions and Resistance Testing

      Spectroscopic Data Evaluation


12:30 - 13:00
Closing Remarks
M. Diem (New York) & K.J.G. Schmailzl (Neuruppin)

15.00 Departure, transfer to Berlin



This minisymposium is intended to provide a platform for critically reviewing the state-of-the-art in biomedical vibrational spectroscopy. Spectroscopic and medical experts are brought together to discuss the potentialities of the new spectroscopic tools and to value prospects of future applications in medical practice.

Organizing committee

Heinz Fabian (Berlin) Jürgen Lichey (Berlin)
Tel.: +30-9406 2851 Tel.: +30-94802 112
Fax: +30-9406 2548 Fax: +30-94802 290
e-Mail: Fabian@mdc-berlin.de
Dieter Naumann (Berlin) Gerwin J. Puppels (Rotterdam)
Tel.: 030/ 18754 2259 Tel: +31-10-4635890/3795
Fax: 030/ 18754 2606 Fax: +31-10-4635307
e-mail: NaumannD@rki.de e-mail: Puppels@HLKD.AZR.NL


This meeting is sponsored by:

Boehringer Mannheim GmbH Bayer Vital GmbH & Co. KG
Glaxo Wellcome GmbH & Co. Merck KGaA
Pierre Fabre Pharma GmbH BioRad Laboratories Europe Ltd.
Novartis Pharma GmbH Bruker Optik GmbH
Mundipharma GmbH Perkin-Elmer GmbH
Pharmacia & Upjohn GmbH A.R.T. - Photonics GmbH
Scherax Arzneimittel GmbH


FT-IR Workshop Series, Berlin, Robert Koch-Institute Home

Any opinions, findings and conclusions or recommendations expressed in this publication are those of the workshop organizers and do not necessarily reflect the views of the Robert Koch-Institute. © 2021 Peter Lasch